IMSI is particularly specified in severe derangement in semen factors and other symptoms are:
- For men with very low sperm count less than 10million and with less than 20% motility.
- For men whose spouses who have had frequent abortions in the first trimester
- For couples suffering infertility, the women having had 2 failed cycles and with the men having low rate of spermatozoa with normal nucleus.
- Elderly men with low sperm count (Oligospermia).
- For couples in which there is no reproduction during earlier cycle whichever through ICSI/ IVF.
- For a couple, having poor fertilization, who is in spite of having a good number of eggs.


